12 It is thus understandable that approximately 85% of type II diabetic patients are insulin resistant and obese. The result is mitochondria that produce large quantities of free radicals. These macrophages become incapable of many cellular functions, including the autophagy that could remove malfunctioning mitochondria. ![]() The chronic inflammatory factors produced by persistent resident macrophages in fat causes insulin resistance. The macrophages in fat tissue become engulfed with ingested fat, developing a “foamy” appearance similar to the fat-filled macrophages in blood-vessel walls that contribute to atherosclerosis. 10 He estimates that fat tissue in lean humans consists of less than 10% macrophages, but that there are nearly 40% macrophages in the fat tissue in very obese humans. Ferrante has shown that macrophages accumulate in fat tissue in proportion to the amount of obesity. ![]() In obesity, expansion of fat cell mass can lead to reduced blood flow 8 and increased fat-cell death, which attracts macrophages to clean-up the dead-cell debris. Macrophages are white blood cells of the immune system that can promote wound-healing during acute inflammation by “eating” pathogens and debris. Macrophages Causing Insulin ResistanceĪnthony Ferrante, MD, PhD (professor of medicine, Columbia University, New York City), has studied the relationship between obesity, macrophages, and insulin resistance. The presentations below are mostly taken from the December 2016 World Congress on Insulin Resistance, Diabetes & Cardiovascular Disease, or the January 2017 Keystone Symposium on Obesity and Adipose Tissue Biology. 6Ĭhronic high blood-glucose due to insulin resistance damages many tissues, which is why so many diabetics suffer from neuropathy, kidney damage, blood-vessel damage, and damage to the pancreas beta-cells such that insulin can no longer be secreted. Insulin resistance most often originates in fat tissue (due to obesity), skeletal muscle, or the liver (due to excess fructose or alcohol consumption), but will eventually cause some insulin resistance in all of the insulin-responsive organs and tissues. For an insulin resistant liver, insulin does not suppress liver-glucose release and increases the conversion of glucose to fat (more fat production). Normally the liver releases glucose into the bloodstream, but when insulin rises after a meal, the insulin should suppress liver glucose release while stimulating the liver’s conversion of glucose to fat. Insulin action on the liver is more complex. ![]() When fat cells become insulin resistant, they dump fats into the bloodstream which become abnormally deposited in other tissues, causing those tissues to become insulin resistant. Glucose entering fat cells is converted to fat for energy storage. Muscle absorbs more glucose with the help of insulin than any other body tissue, so insulin resistance of muscle results in the greatest elevation of blood glucose and insulin. 5 It’s a vicious circle of obesity increasing insulin resistance and insulin resistance increasing obesity.Ī major function of insulin is to cause glucose to enter cells. 4Įlevated blood insulin due to insulin resistance or other causes increases obesity, whereas a reduction in blood insulin can enable weight loss. Obesity can shorten lifespan by many years. The major cause of insulin resistance is obesity, 1 either because of excess fat interfering with insulin action, 2 or because of interference of insulin action by inflammation resulting from obesity 3 or both. ![]() In type II diabetes, not only do beta-cells not function well, but various organs of the body become resistant to insulin action. In type I diabetes, there is no insulin production by beta-cells in the pancreas. Insulin-related defects are associated with diabetes. Insulin is a major hormone controlling systemic metabolism.
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If you have a dirty seal or ring or anything it won’t seal and the soup can burn on the bottom of the stainless steel insert which I have done before so learn from my mistakes! Once you hear it seal you can leave it and carry on with something else. Make sure to listen and hear your Instant Pot SEAL and come to pressure.Use lean ground beef in this Instant pot macaroni hamburger soup to cut down on the fat amount in the recipe but if you have to use regular, make sure to drain it well!.Next, saute your vegetables, starting with the onion and celery. 1 ½ teaspoons dried minced onion 1 garlic clove, pressed 2 (10. Use the mixed frozen vegetables mix as using frozen vegetables will help them stay firm and not mushy during the cooking time. Start by sauteing your ground beef, drain the grease, and set aside. Ingredients 1/2 onion finely diced 1 Tbsp 14.79 ml coconut oil or avocado oil 1 lb 454.00 g ground beef 1 1/2 tsp 7.39 ml sea salt 5 cups 1200.00 ml water.I’m so glad to hear that the Hamburger Soup recipe was a hit for your mom during her chemo treatment It’s wonderful that she enjoyed it and even finished. Macaroni, shells and rotini are favorites to make this into a delicious and hearty macaroni. Always use the soup button when making soup in your pressure cooker or Instant Pot. I add an extra 1 cup of broth (or water) and let the pasta simmer until tender.Tips And Tricks for Instant Pot Macaroni Hamburger Soup Steamer Rack for Instant pot, Dimeshy 2 PACKS Stackable Egg Steamer Rack Trivet for Pressure Cooker.Genuine Instant Pot Sealing Ring 2-Pack – 6 Quart Red/Blue.Genuine Instant Pot Silicone Lid 5 and 6 Quart.Genuine Instant Pot Tempered Glass lid, Clear – 9 in. Full nutritional breakdown of the calories in Hamburger Macaroni Soup based on the calories and nutrition in each ingredient, including Ground beef, lean. This soup recipe is a simple and hearty meal made with ground meat, veggies, and macaroni noodles in a tomato broth. ![]() ![]() Brown the Ground Beef: Add the ground beef to the soup pot and cook it until it turns golden brown.
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Write, compile, package and deploy enterprise grade, cross-platform native applications with flexible cloud services and broad IoT connectivity from the first IDE with integrated Windows 10 Desktop Bridge packaging. You can also download FmxLinux 1.31 for RAD Studio 10.2.3.ĭelphi is the nimble Object Pascal IDE and component library for cross-platform native application development you’ve come to expect. ![]() Fast developers choose Delphi for Enterprise Strong Development™ and enjoy 5x faster development cycles across desktop, server, mobile, cloud, and database platforms. Compile natively for fast Linux and Windows server support and reach the widest audience with App Store support for Windows 10, macOS, iOS and Android – all from the same native code base – in the only IDE with integrated Windows 10 Desktop Bridge Support. Embarcadero Delphi 10.2 Tokyo is the nimble Object Pascal IDE and component library for cross-platform native app development with flexible Cloud services and broad IoT connectivity. Embarcadero Delphi 10.2.3 Lite 14.4 Free Download OverviewĮmbarcadero® Delphi 10.2 Tokyo delivers the most powerful Object Pascal language and component library for fast cross-platform native app development with flexible cloud services and broad IoT connectivity. It is full offline installer standalone setup of Embarcadero Delphi 10.2.3 Lite 14.4 Free Download for supported version of windows. The program and all files are checked and installed manually before uploading, program is working perfectly fine without any problem. Embarcadero Delphi 10.2.3 Lite 14.4 Free Download Latest Version for Windows. 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![]() The only thing you can see is the lantern not really the people in the pictures. People were just walking through when other people are trying to take pictures, not even saying excuse me which was very rude.Īlso for better pictures and lighting it's probably a good idea to put lights on both sides of any area that has a festival lantern because if there's no lighting on the other side all pictures come out really dark. The lantern festival is very pretty but I would never go again to the Palm springs location because the patrons really don't have any manners, (adults and children). It might even be a great idea to implement photographers as well as people being able to take their own pictures. Or they should definitely have some kind of structure when people are taking pictures or people are waiting in line to take photos. They should definitely have a capacity of how many people can come in. We even came back for the second evening light festival. We tried to tell Chad and David her bosses but we could not find them anywhere at the zoo throughout the time we were there from 1:00 p.m. She's very nice and has really great customer service. Shout out to Christina the young lady who works in the refreshment stand that's near the camels and in between the goat petting area. I normally don't go to zoos only sanctuaries. I hope all animals are treated well at all times. ![]() The staff and volunteers are extremely nice. Other than that, I gave Balboa Park an A+ because it really impressed me. It probably took us around 20 minutes to see the entire Museum, compared to the natural Museum in L.A., this place was very small and was in need of more exhibits. We went inside the natural history Museum and paid the admission but was a little disappointed with it. There are many areas to sit under the shade and relax on the grass or a bench. Although I saw many snack vendors, I didn't see many good restaurants so I would recommend bringing some sandwiches or whatever you can bring to eat. I highly recommend this place if you have a day to kill and spend some quality time with the family or significant other. I went there on a Tuesday and it was very crowded, so weekends must get really packed. There is a tram that takes you to all the parking lots. We didn't even have time to see everything. It was nothing of what I expected, the Balboa park connects several Cathedral style venues on this wonderful walkways that include the San Diego Zoo, the Natural History Museum and several other museums. Bring your walking shoes and get ready to walk through the many Museums, theaters, shops, and wonderful views this place has to offer. If you are visiting San Diego this place is a must see. All in all, this place is worth checking out when you’re in the San Diego area! They have more events now than back then. There are a lot of rides for children and adults. Although, they can take the time to clean the glass of their tanks. They seem healthy, active, and stimulated. You can tell by the way they interact with their trainers. ![]() But a couple years ago I remember them being a bit more impressive because during the dolphin show, performers were diving way up high and it was just more entertaining.Īll the animals seem very happy to me. They had a good amount of rides for the little ones that my husband and I were able to get on also. We went during the Sesame Street event and it was such perfect timing. Fast forward a couple years and now I have two little girls. Went here a couple years ago without kids and enjoyed their shows, animals, rides and amenities. I do appreciate the opportunity to see unique animals, and respect their conservation efforts. We’ve started to leave the park to eat, but that might not be an option for a day visit, where you can easily loose an hour or more. The shows play a few times each day, so check the website for that, or you can ask an employee. The list the attractions that are closed at the entrances to the parking lot, so check that out as you enter. We found navigating the park to be a little confusing, so download a map ahead of time, and check out where some of the most popular attractions are (Electric Eel, Journey to Atlantis, Manta). Though choosing to go off season, not the summertime, the park doesn’t see to be overly crowded, and even better on a weekday. I recommend getting there at least a half an hour early, so you can be a head of the crowds, especially if you want to hit one of the most popular rides. The biggest draw is the opportunity to create great family memories while learning about sea life, and potentially sparking an interest in our kids. The passes were a great deal price wise, and they don’t require reservations to enter. I’ve been several times when I was younger, and we have been going once a month since we got passes back in September. SeaWorld San Diego is a top place to visit when you’re in Southern California. Enhanced reporting so you can create beautifully customized financial reports (something you don’t get with the Simple Start or Self-Employed plans.).Connect your business bank accounts to the software to automatically sync your transactions.It’s almost always the best fit for my clients because it has all the features you’ll need, including: The short answer: The Quickbooks Online ‘Essentials’ subscription. But which QBO subscription is the best choice? Please contact us for more information about our services.QuickBooks Online is an excellent tool to keep on top of your bookkeeping for your private practice. Our team has years of experience and strives to keep our clients informed of the ever-changing tax environment. TMDL provides tax planning and preparation for both individuals and businesses. Always contact an experienced tax advisor if you are unsure of your tax liability. It’s important to remember that different tax rules apply to different types of businesses and state tax laws governing LLCs may vary. and European multinational firms use outsourcing or shared services for financial functions. There is a lot to know when it comes to tax laws, that’s why acording to Global Business News, 75 percent of U.S. AnĮxperienced tax professional can help you determine if your organization could Level and individually on each shareholder’s personal tax statement. C Corps pay taxes on business profits on both a corporate That not all LLCs will benefit from this election. ![]() Much like an S Corp, each shareholder paysĪ portion of the FICA taxes on their wages. While C Corps pay income tax on all profits, these profits do notįlow through the owners’ tax return. While owners must still pay income taxes on distributions received outside of their wages, they may not have to pay self-employment tax on these earnings.Īnother option, LLCs can elect classification as a CĬorporation. One benefit of this model, only the salary of the owner(s) is subject to self-employment tax. They then distribute the remaining profits to other shareholders or partners. With an S Corp, the owner(s) pay themselves a salary out of all business earnings. Making an S Corp election with the IRS cannot eliminate self-employment tax liability completely, but it may allow you to reduce the amount you owe. Or other business activities in which the owner of the LLC is not actively However, passive income is not subject to self-employmentĮarned from rental properties, real estate investments, limited partnerships, LLC owners must pay self-employment tax on most, if not all,īusiness income. Partners of partnerships, S corporation owners, and most limited liability Include sole proprietors, independent contractors and freelancers, individual Pass-through business types subject to self-employment tax The IRS income limit for the reduced amount variesįrom $125,000 to $250,000 depending on filing status. However, if business income exceeds a certain amount, taxpayers must pay anĪdditional Medicare tax of 0.9%. 12.4% of this amount goes to Social Security and 2.9% goes to Medicare. Self-employment tax is calculated at 15.3% of net business Instead, the owners of pass-through entities must pay Taxes get automatically deducted from each paycheck. When you work for an employer, Medicare and Social Security In fact, this is one of the most common tax-related questions. Many struggle to understand whether or not they need to pay self-employment While most LLC owners understand their income tax liability, Each member or co-owner of the multi-owner LLC pays taxes on their share of the profits through a Schedule E, which is then filed with their personal income tax return. This isn’t much different than multi-owner LLCs, which are treated like partnerships for tax purposes. This is then submitted with their 1040 individual tax return. For single-owner LLCs, the sole owner reports all profits of the LLC on a Schedule C. Through treatment, allowing owners to avoid double taxation.ĭepending on the number of members, the IRS treats an LLC like a sole proprietorship or partnership. In addition to limiting personal liability, LLC’s receive pass ![]() Operating under an LLC business structure provides numerousīenefits. ![]() Sigma membership is by invitation to baccalaureate and graduate nursing students who demonstrate excellence in scholarship and to nurse leaders exhibiting exceptional achievements in nursing. The installation marked the accomplishment of many years of hard work.Ĭurrently, we have 355 active members in Delta Psi. After the installation, a reception and luncheon was held at the LafayetteClub. Jean McKinley, former vice president of Sigma, presided as the installing officer for the 276 charter and transfer members. The UK College of Nursing Honor Society was approved for chartering.Īlong with the presentation of the charter, the induction of members and installation of officers followed. Kay Robinson represented the Honor Society at the Sigma Biennial Convention in Seattle, Washington. In July 1979, then President Gretchen LaGodna received word that our application for membership would be recommended for approval by the National Council of Sigma. McKinley presented the keynote address: Why an Honor Society in Nursing? The induction ceremony for 221 candidates into the newly formed UK College of Nursing Honor Society was held on at the Student Center Ballroom with Dean McKenna presiding. Evelyn Geller was elected Chair of the Steering Committee and bylaws were drafted. The purpose was to recognize excellence in nursing and eventually, to petition a charter from Sigma, the National Honor Society for Nurses. McKinley's encouragement, a group of nine UK faculty members met as a steering committee to form our Honor Society in Nursing on Nov. Jean McKinley, first vice president of Sigma, to initiate plans for establishing a chapter of the national honor society in nursing. Marion McKenna, dean of the College of Nursing, along with two faculty members, met with Ms. Sigma became incorporated in 1985 as a nonprofit organization with a 501(c)(3) tax status in the United States. In 1922, six nurses founded the Honor Society of Nursing, Sigma Theta Tau International, today known as Sigma, at the Indiana University Training School for Nurses, which is now the Indiana University School of Nursing, in Indianapolis, Ind., USA. The founders chose the name from the Greek words storgé, tharsos, and timé, meaning love, courage, and honor. Sigma's vision is to be the global organization of choice for nursing. The mission of the Honor Society of Nursing, Sigma, is advancing world health and celebrating nursing excellence in scholarship, leadership, and service. Visit the Delta Psi Chapter pageon the Sigma website for the most up-to-date chapter information. ![]() If you have your PDF file handy, you can. Besides PowerPoint, Zamzar allows to convert. You can do this by uploading it from your computer, or through a cloud storage service such as Google Drive or Dropbox. For this tutorial, I downloaded a free corporate Keynote template from Louis Twelve which I found on Behance. I’ll be dividing this section into two how to convert on both MacOS and iOS. ppt files by itself, but using other other online tools like Zamzar then it is possible to convert Keynote to PowerPoint, as detailed in their article supporting Keynote conversion to PowerPoint presentations. Step-by-step guide to convert Keynote to PowerPoint. ![]() ![]() However, the exported presentation may not keep all the original transitions and animations available on Keynote so this procedure is better to export simple presentations. Step 3: Once you open the PPT, you will face several warnings. Select ‘Open’, and on the drop menu, click on ‘On My Mac’. Step 1: Run keynote app on Mac and click on ‘File’. ppt presentations compatible with Microsoft PowerPoint. If you want to convert a PowerPoint document in a PPT on Mac, then follow the steps below. I saw the option for Power Point, chose that one and selected Ok when given the choice. Keynote is only available on OS X and there is no native version of Keynote on Windows, however if you have Keynote in your Mac you can then export your. I just converted my Keynote presentation to Power Point by opening Keynote, selecting File, then moved down to Export to. PowerPoint is historically available on Windows but also in Mac with the PowerPoint 2011 for Mac version. Keynote Theme: Your presentation is saved as a theme in the Theme. To include each build animation as a single image, turn on Include Builds. Choose an image format (the higher quality the image, the larger the file size). Tap Slide Range to choose the slides you want to export as images. key files are a very popular presentation format used by Mac users, however sometimes we require to open Keynotes in Microsoft PowerPoint. Images: Slides are exported as JPEG, PNG, or TIFF files. It is an excellent choice for those who are looking to go beyond the basic functions However, those who are mostly interested in WOL features will discover that all the other features hinder your work. The ability to function and be flexible even when far from a computer is among the most effective tools available in our day-to-day lives. Network Management Software Buyers Guide White Paper Are you having trouble deciding on the appropriate software for your network? Download this White paper and analyze your options, along with the specific requirements for your specific environment. Make use of Deep Packet Analysis for Monitoring Client/Server Connections Discover how to make use of Deep Packet Analysis to discover and track the ways that users connect to your servers and your interfaces on an individual scale. If you’re in an office or shared network, you may request the administrator of your network to conduct a scan of the network to find out if there are any misconfigured or affected devices. Atera provides everything you require to resolve your clients’ most complex IT challenges in one central place. Atera is a cloud-based all-in-one remote management and monitoring platform for MSPs and IT Service Providers. Aquila Technology Wake-on-LAN Provides access to the WoL feature through an intuitive GUI that shows the status of network-connected PCs as well as their network through MAC address. It is able to work as remote devices which can be accessed remotely, even via the Internet. SolarWinds Wake-On LAN is a delightful application that comes with an intuitive interface that allows you to control computers that are connected to the same network as the administrator’s PC. the whole network, turning everything on. The WOL message is sent to specific devices, the entire network, or to groups of devices. The service can start endpoints that are completely shut off, so they are connected to a power source. In addition, there is a column called ‘Index that indicates the order in which that computer was added to the list. Version 1.35Added “Add New Computer’ option (Ctrl+N) that allows you to add manually a an additional computers in the list. ![]() In the following video, we will demonstrate how this is possible, and will also show how to set up a computer to use WoL packets. Alongside using a PC or laptop to transmit WoL packets to administrators, they can make use of their smartphones to control the machines that are on their network. cfg file without having to display a user interface. Version 1.11Added the command-line option /scan that scans your network automatically and then updates the. You might have to download version 2.0 right now through on the Chrome Web Store.Īfter installing the software, the network NIC is still receiving energy even when the power is off, and is waiting for a certain packet to be sent which will trigger a start-up. Another method to avoid getting this website, later on, is to make use of a Privacy Pass. Aquilatech WOL A free Ping and Wake-on-Lan application with an attractive user interface. ![]() HM Software NL Wake On LAN It is a beautiful and simple-to-use free Wake-on-LAN tool. It requires your Mac Address of the remote computer, and ensure that you have the Wake On Lan is configured correctly for each networking Interface as well as the BIOS. ![]() Utilizing NinjaOne, MSPs and IT departments can streamline, manage and improve tasks associated with managing their endpoints using one modern, fast user-friendly platform and improve the quality of technicians… WakeUp utility is quite old and inefficient and is hosted by The Utility starts the Magic Packet to wake up remote PCs through Command-line, as well. ![]() NinjaOne is the most popular integrated IT operation solution that streamlines the way IT teams operate. If you want to enable WoL, you’ll likely need to dig deeper to locate the exact menu item that has the options (it typically falls in advanced power options and the default option will be “Disabled”). Once it has been found, it will locate their MAC addresses using any of the four options – Neighbor Discovery, NetBIOS WinAPI, WinAPI, or WMI. The scanner scans your network for computers that belong to workgroups or domains. If your computers are switched off, WakeMeOnLan allows you to search your network, and then collect the MAC addresses of all your computers and save the list of computers to a database. You can select several items and then modify both the number of ports and the address for broadcasting the selected items simultaneously. Syxsense Manage–FREE TRIAL An endpoint management package tool that includes Wake-on-LAN as well as other remote management tools. SolarWinds Engineer’s Toolset includes more than 60 network management tools, and one of them is a Wake-on-LAN-based service. ![]() ![]() On the Playback tab, select and hold (or right-click) the Default Device, and then select Properties. Select Hardware and Sound from the Control Panel, and then select Sound. In the search box on the taskbar, type control panel, then select it from the results. Sometimes having audio enhancements on can result in audio issues. For more info, see "Restore from a system restore point" in Recovery options in Windows. Try restoring from that point and see if that fixes your sound problems. When Microsoft installs updates on your system, we create a system restore point in case problems arise. Restore your PC from a system restore point: If rolling back your audio driver didn't work or wasn't an option, you can try to restore your PC from a system restore point. Read and follow the instructions and then select Yes if you want to roll back your audio driver. Select the Driver tab, then select Roll Back Driver. Select and hold (or right-click) the listing for your sound card or audio device, then select Properties. If your audio was working before you ran Windows Update and now isn’t working, try rolling back your audio driver. ![]() If you have audio issues after installing updates The following is an example of a driver download page for a sound device manufacturer. If these steps didn't solve your audio issue, visit your device manufacturer’s website and install the most recent audio/sound drivers for your device. Select the audio device whose driver you want to update, select Next, and then follow the instructions to install it. Select and hold (or right-click) the listing for your sound card or audio device, then select Update driver > Browse my computer for drivers > Let me pick from a list of available drivers on my computer. To use the generic audio driver that comes with Windows: If those options didn’t work, try using the generic audio driver that comes with Windows. To restart, select Start > Power > Restart. This restart will automatically prompt your PC to reinstall your audio driver. Note: Be sure to save your documents and any other current work before you restart. Select and hold (or right-click) the listing for your sound card or audio device, select Uninstall device, select the Attempt to remove the driver for this device check box, and then select Uninstall. ![]() If that doesn't work, try uninstalling your audio driver. If Windows doesn't find a new driver, look for one on the device manufacturer's website and follow those instructions. Follow the instructions to complete the update. Select and hold (or right-click) the listing for your sound card or audio device, such as headphones or speakers, select Update driver, then select Search automatically for drivers. Select the arrow next to Sound, video and game controllers to expand it. In the search box on the taskbar, type device manager, then select it from the results. To update your audio driver automatically: If you're having audio issues after installing updates, try rolling back your audio driver. If that doesn't work, try using the generic audio driver that comes with Windows. If that doesn't work, try uninstalling the audio driver (it will reinstall automatically). Make sure your audio driver is up to date and update it if needed.
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